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Pesquisa
Probiotics for management of functional abdominal pain disorders in children
Gordon M, Wallace C, Sinopoulou V, Akobeng AK. Cochrane Database of Systematic Reviews 2023, Issue 2. Art. No.: CD012849. DOI: 10.1002/14651858.CD012849.pub2. Accessed 02 March 2023
A B S T R A C T
Background
Functional abdominal pain is pain occurring in the abdomen that cannot be fully explained by another medical condition and is commonin children. It has been hypothesised that the use of micro-organisms, such as probiotics and synbiotics (a mixture of probiotics andprebiotics), might change the composition of bacterial colonies in the bowel and reduce inflammation, as well as promote normal gutphysiology and reduce functional symptoms.
Objectives
To assess the efficacy and safety of probiotics in the treatment of functional abdominal pain disorders in children.
Search methods
We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and two clinical trials registers from inceptionto October 2021.
Selection criteria
Randomised controlled trials (RCTs) that compare probiotic preparations (including synbiotics) to placebo, no treatment or any otherinterventional preparation in patients aged between 4 and 18 years of age with a diagnosis of functional abdominal pain disorder accordingto the Rome II, Rome III or Rome IV criteria.
Data collection and analysis
The primary outcomes were treatment success as defined by the primary studies, complete resolution of pain, improvement in the severityof pain and improvement in the frequency of pain. Secondary outcomes included serious adverse events, withdrawal due to adverseevents, adverse events, school performance or change in school performance or attendance, social and psychological functioning orchange in social and psychological functioning, and quality of life or change in quality life measured using any validated scoring tool. Fordichotomous outcomes, we calculated the risk ratio (RR) and corresponding 95% confidence interval (95% CI). For continuous outcomes,we calculated the mean difference (MD) and corresponding 95% CI.
Main results
We included 18 RCTs assessing the effectiveness of probiotics and synbiotics in reducing the severity and frequency of pain, involving atotal of 1309 patients.
Consulte o artigo em: https://doi.org/10.1002/14651858.CD012849.pub2
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