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Associations of Infant Colic and Excessive Crying With Atopic Outcomes in Childhood and Adolescence

Switkowski KM, Oken E, Simonin EM, Nadeau KC, Rifas-Shiman SL, Lightdale JR. Associations of Infant Colic and Excessive Crying With Atopic Outcomes in Childhood and Adolescence. J Pediatr. 2025 Apr 23;283:114623. doi: 10.1016/j.jpeds.2025.114623. Epub ahead of print. PMID: 40280470.

Abstract

Objective

To assess the extent to which risks of atopic and respiratory conditions throughout childhood and adolescence differ by history of (1) infant colic, characterized by apparent abdominal discomfort and unsoothable crying, (2) excessive crying without colic, or (3) neither condition.
 
Study design
 
Among 1249 children participating in the prospective, unselected Project Viva cohort, we examined associations of history of infant colic or excessive crying without colic with risks of eczema, allergic rhinitis, asthma, and respiratory infections, measured in toddlerhood, early childhood, mid-childhood, early adolescence, and mid-adolescence using multinomial logistic regression models.
 
Results
 
The study sample was 50% female and 71% non-Hispanic White; 26% had colic and 9% excessive crying. Children with colic (vs no colic or excessive crying) had higher risk of eczema (relative risk ratio [RRR], 2.1; 95% CI, 1.2-3.8), allergic rhinitis (RRR, 1.6; 95% CI, 1.1-2.4), and asthma (RRR, 1.6; 95% CI,1.1-2.4) in mid-childhood, and a higher risk of respiratory infections in toddlerhood (RRR, 1.6; 95% CI, 1.2-2.2) and mid-adolescence (RRR, 2.1; 95% CI, 1.2, 3.7). The risk of 2-3 concurrent atopic conditions (eczema, allergic rhinitis, and/or asthma) was nearly twice that among the colic group (vs unaffected) at all life stages. The group with excessive crying without colic did not have increased risk of atopic and respiratory outcomes.

Conclusions
 
Colic characterized by unsoothable crying and parent perceptions of abdominal distress may be an early marker of atopic susceptibility.
 
Keywords
 
cohort study / Project Viva / eczema / allergic rhinitis / asthma / respiratory infection
 

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